Transdermal patch ultra high speed colloid mill

Patch homogenizer, transdermal patch colloid mill, pharmaceutical colloid mill, German high-speed colloid mill,Pressure sensitive adhesive matrix colloid mill,The matrix colloid mill of the patch isThe motor drives the rotating teeth (also known as the rotor) to rotate at high speed relative to the matching fixed teeth (also known as the stator) through a belt drive. The processed material is pressurized by its own weight or external pressure (which can be generated by a pump) to produce a downward spiral impact force. Through the adjustable gap between the fixed and rotating teeth, it is subjected to strong physical effects such as shear force, friction force, and high-frequency vibration, effectively emulsifying, dispersing, and crushing the material, achieving the effect of ultrafine crushing and emulsification of the material.

Patch refers to a thin, sheet-like preparation that can be applied to the skin and produce systemic or local effects of the drug. Modern transdermal absorption preparations are patch or patch drugs that are absorbed through the skin and can be rapidly and persistently administered to the whole body through a controlled release mechanism according to the required dosage of the disease.

The commonly used pressure-sensitive adhesive matrix for patches is a key material in transdermal absorption systems. It refers to a type of adhesive material that can achieve adhesion under slight pressure and is easy to peel off, thereby ensuring close contact between the drug release surface and the skin, drug storage, and controlled release. The molecular weight and molecular weight distribution, crystallinity and crystallinity, crosslinking degree, and glass transition temperature of polymer materials have important effects on the transdermal absorption of drugs. Generally, various pressure-sensitive adhesives are selected based on the solubility, dispersion coefficient, and permeability coefficient of the drug in the pressure-sensitive adhesive matrix.

The patch should comply with the following relevant regulations during production and storage.

1、 The materials and excipients used in patches should comply with relevant national standards, be non-toxic, non irritating, stable in nature, and not work with drugs. The commonly used materials include aluminum foil polyethylene composite film, release paper, ethylene vinyl acetate copolymer, acrylic or polyisobutene pressure-sensitive adhesive, silicone rubber, and polyethylene glycol.

2、 The patch can be supplemented with surfactants, emulsifiers, moisturizers, preservatives, or antioxidants as needed. Transdermal patches can also incorporate transdermal enhancers.

3、 The appearance of the patch should be complete and smooth, with a uniform application area, and the punching incision should be smooth without sharp edges.

4、 Medications can be dissolved in solvents and filled into storage facilities. There should be no bubbles or leaks in the drug storage facility. The drug suspension in the formulation must ensure uniform suspension and coating.

The refining effect of colloid mill is generally weaker than that of homogenizer, but it has strong adaptability to materials such as high viscosity and large particles. Therefore, in many occasions, it is used in the front of homogenizer or in high viscosity situations. Colloidal mills are often used for refinement when there are many solid substances.

The XMD2000 series is specifically designed for the production of colloidal solutions, especially those that require good emulsification and dispersion effects. The linear speed of XMD2000 is very high, and the shear gap is very small. Therefore, when the material passes through, the frictional force formed is relatively intense, resulting in what is commonly known as wet grinding. The fixed rotor is made into a circular cone shape, with three-level sawtooth protrusions and grooves with increasing precision. The stator can be infinitely adjusted to the desired distance between it and the rotor. Under enhanced fluid turbulence, grooves can change direction at each stage. High quality surface polishing and structural materials can meet various requirements of different industries.

A grinding rotor with a three-level misaligned tooth structure, matched with a precise stator cavity. This vertical colloid mill has a speed that is more than three times faster than ordinary horizontal colloid mills, and the maximum speed can reach 14000 RPM. So it can achieve better dispersion wet grinding effect.

Grinding and dispersing machine is a high-tech product composed of colloid grinding and dispersing machines.

The first level consists of three-level sawtooth protrusions and grooves with increasing precision. The stator can be infinitely adjusted to the desired distance between the rotors. Under enhanced fluid turbulence. The groove can change direction at each level.
The second stage is composed of a stator. The design of the dispersing head also effectively meets the needs of substances with different viscosities and particle sizes. The difference in the design of the stator and rotor (emulsifying head) between online and batch machines is mainly due to the requirements for conveying performance. It is particularly important to note that the difference between coarse precision, medium precision, fine precision, and other types of working heads is not only the arrangement of specified rotor teeth, but also an important difference in the geometric characteristics of different working heads. The width of the slot and other geometric features can alter the different functions of the stator and rotor working heads.

The following is a model table for reference:

Transdermal patch ultra high speed colloid mill